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Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling Invasive breast cancer is highly regulated by tumor-derived cytokines in tumor microenvironment. The development of drugs that specifically target cytokines are promising in breast cancer treatment. In this study, we reported that arctigenin, a bioactive compound from Arctium lappa L., could decrease tumor-promoting cytokines GM-CSF, MMP-3, MMP-9 and TSLP in breast cancer cells. Arctigenin n…
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15.11.2020 · From Theo Verwey
Naringin inhibits thyroid cancer cell proliferation and induces cell apoptosis through repressing PI3K/AKT pathway The present study aimed to investigate the anti-tumor effects of naringin in thyroid cancer (TC), and to explore the underlying mechanisms. TC cell lines TPC-1 and SW1736 were treated with 6, 12 or 25 μg/ml naringin for indicated times. Then, cell proliferation was determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, and cell apoptosis was…
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08.11.2020 · From Theo Verwey
NAD+ and NADH Concentrations in Younger and Older Human Adults NADH and NAD+are the most important coenzymes in the biological system. We have studied the concentration of these coenzymes in human serum from different age groups (20 years to 80 years old). Two analytical methods (HPLC and an enzymatic) were developed for this purpose. NADH was found to be very unstable in serum samples even when analyzed immediately after their collection. Serum NADH undergoes oxidation in vitro irrespective of…
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05.11.2020 · From Theo Verwey
Three-dimensionally resolved NAD(P)H cellular metabolic redox imaging of the in situ cornea with two-photon excitation laser scanning microscopy. Three-dimensional maps of cellular metabolic oxidation/reduction states of rabbit cornea in situ were obtained by imaging the fluorescence of the naturally occurring reduced pyridine nucleotides (both reduced nicotinamide-adenine dinucleotide, NADH, and reduced nicotinamide-adenine dinucleotide phosphate, NADPH, denoted here as NAD(P)H). Autofluoresce…
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05.11.2020 · From Theo Verwey
Prooxidant activity of fisetin: effects on energy metabolism in the rat liver. Flavonols, which possess the B-catechol ring, as quercetin, are capable of producing o-hemiquinones and to oxidize NADH in a variety of mammalian cells. The purpose of this study was to investigate whether fisetin affects the liver energy metabolism and the mitochondrial NADH to NAD+ ratio. The action of fisetin on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In isol…
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04.11.2020 · From Theo Verwey
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FirstNAD Ambasador

"NAD Oscillation* Like the ebb and flow of the sea, our cells need a recurrent pattern of movement back and forth in a regular rhythm to get rid of toxins and for regrowth. Better absorption is better regulation of all the tiny molecules needed to activate, to silent and harmonize. See nature. See the body."

Theo Verwey


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